Automated contingency management using smartphones may reduce barriers and improve opioid use disorder treatment

Contingency management is among these most effective interventions for many types of substance use disorders. Barriers to its implementation, however, reduce the likelihood that treatment programs will adopt this empirically supported intervention. In this study, researchers evaluated the acceptability and effectiveness of an automated contingency management smartphone application to improve opioid use disorder (OUD) treatment.

WHAT PROBLEM DOES THIS STUDY ADDRESS?

Despite compelling evidence supporting the effectiveness of contingency management for many types of substance use disorders, key barriers to adoption include negative, often incorrect, beliefs and biases about its efficacy, and costs. Automation of contingency management using smartphone applications provides a means of circumventing barriers to implementation, such as provider beliefs, training levels, limited provider time (e.g., of training and implementation), and can be used as add-ons to standard care. At the same time, there is little information about these automated contingency management interventions, and a need to evaluate their use and efficacy for OUD treatment. These researchers sought to address this knowledge and service gap by conducting a pilot study to evaluate the efficacy and acceptability of an application that incentivized abstinence from opioids and other drugs, adherence to the OUD medication buprenorphine, as well as treatment session attendance during outpatient OUD treatment.

HOW WAS THIS STUDY CONDUCTED?

This study was a non-randomized pilot trial of an automated contingency management application plus standard outpatient care, compared to standard care among patients in another nearby outpatient clinic (control condition). Both inner-city substance use disorder clinics provided outpatient, intensive outpatient, and continuing care treatment to patients with OUD. The researchers compared outcomes of their app-based intervention by matching participants in their study with patients from the nearby clinic. Specifically, the researchers matched individuals in the treatment condition to individuals at the other clinic (the control condition) by first selecting patients who entered treatment on the same day, had a urine test on or before the day the participant in the treatment condition started using the app, enrolled in the same level of care (e.g., outpatient, intensive outpatient), and had the same primary diagnosis of OUD. This matching strategy worked for all but eight participants in the treatment condition, who were subsequently removed from the analysis, resulting in 85 matched pairs (N = 170).

For 4 months, the application was used as an add-on to standard care, which included individual and group counseling, medication (e.g., buprenorphine), onsite urine testing, and optional paper-and-pencil Cognitive-Behavioral Treatment (CBT) materials (e.g., worksheets). Usability and acceptability, which included measures of how usable the platform was and participants’ likelihood of recommending it to a friend, was assessed during post-pilot study focus group meetings. The researchers also examined abstinence and use of medication for OUD (as measured by urine toxicology results), treatment attendance, and intervention acceptability and satisfaction.

The application was designed to deliver financial incentives for consistent abstinence from drugs, persistent use of medications for OUD (i.e., buprenorphine), verified attendance at scheduled (i.e., clinic-based) and optional treatment (mutual help groups), and use of CBT modules within the app.

For contingency management, participants could earn up to $100 per month for providing recovery-consistent urine results (i.e., abstinence and evidence of buprenorphine adherence, as confirmed by clinic) and treatment attendance (measured by GPS, confirmed by clinic staff), and an additional $1 for each CBT module completed (i.e., up to $36). GPS was used in this study, which included the same technology as “maps” applications on smartphones, to determine whether the participant was present at the treatment facility. Monetary incentives were transferred to patients’ reloadable Visa smartcards, which blocked cash withdrawals and limited expenditures to prevent suspect purchases or use at bars, liquor stores, casinos, etc.

Participants included 85 matched pairs, for a total of 170 participants. All participants had an OUD (diagnosed at clinic intake), while half of the study participants were women (51%) and 61% were White/Caucasian. Participants were 38 years old on average (SD = 9.5). The participants in the treatment and comparison group were similar on all measured domains, with the exception of individuals in the intervention group having a higher percentage of prescribed buprenorphine use.

WHAT DID THIS STUDY FIND?

Patients with OUD who received automated contingency management via the app were more likely to provide abstinent/medication adherent urine results for the duration of the study. These patients also reported significantly higher rates of scheduled session attendance.

Users of the contingency management intervention reported a high level of acceptability and satisfaction with the intervention, including on measures of whether they would refer a friend to use the app and overall satisfaction. The researchers also noted that of the 13 participants who left treatment prematurely and returned, each requested to use the application again. The clinic staff reported that the overall burden of the intervention was “negligible,” requiring little to no time or effort on the part of providers. The researchers stated that anecdotally, CBT module usage was greater with the app than in standard care, using the paper-and-pencil CBT content.

Figures 1 and 2.

WHAT ARE THE IMPLICATIONS OF THE STUDY FINDINGS?

Automation of contingency management and delivery via smart phone applications appears to be acceptable to patients and is associated with higher rates of abstinence/medication adherent urine results and treatment attendance compared to standard outpatient care. Importantly, the researchers stated that their incentives were lower than in comparable studies, which could have reduced the observed group differences among patients. It is possible that effects would have been more pronounced with larger incentives. In either case, automation and ease of implementation of app-based contingency management may circumvent key implementation and procedural barriers, including logistical constraints, fidelity of and timely reinforcement, and lack of provider training, or other attitudinal biases that might otherwise limit the adoption of efficacious contingency management.

Contingency management is most often applied to target one or two circumscribed target behaviors, such as consistently negative urine toxicology results or treatment attendance. The approach in the current study was to target these behaviors, as well as engagement in the CBT modules of the app, and participation in additional interventions (mutual help group attendance) of their choosing. This approach resulted in significant improvements on several target behaviors, including both therapy process behaviors (treatment session attendance, which is associated with improved recovery outcomes) and outcomes (urine toxicology results). Although the study used a matched control condition and did not use a more scientifically rigorous randomized design, the findings remain suggestively compelling. In addition, the reported acceptability and satisfaction among app users provides further evidence of the potential utility of automated contingency management to supplement standard outpatient treatment for OUD.

LIMITATIONS

1. Participants were not randomized and comparisons between conditions were made between patients being treated at different facilities. While the two groups were similar on most measured characteristics, increasing confidence the advantage for the CM smartphone intervention was indeed due to the intervention itself, participants could have differed on other unmeasured characteristics. For example, there might have been important differences between the clinicians, services offered, or other factors unique to each site.
2. The application used and evaluated in this study was considered an add-on to standard care and was not used in an integrated fashion with standard care.
3. The researchers made two modifications to the intervention during the study; the first was that they limited the number of optional sessions patients could be compensated for, and also increased the number of CBT modules from 36 to 90. These modifications have unknown implications for study findings but are noted in light of possible effects on the observed outcomes.

BOTTOM LINE

Contingency management involves providing timely incentives to individuals for health behavior change, such as treatment engagement and illicit opioid abstinence. The results of this study support the notion that automated contingency management, provided via a smartphone application, can help improve treatment attendance and lead to higher rates of abstinence/medication adherent urine results.

CITATIONS

DeFulio, A., Rzeszutek, M. J., Furgeson, J., Ryan, S., & Rezania, S. (2021). A smartphone-smartcard platform for contingency management in an inner-city substance use disorder outpatient program. Journal of substance abuse treatment, 120, 108188. doi:10.1016/j.jsat.2020.108188